小梁切除术中应用丝裂霉素C与术后应用肝素的对比研究

目的：探讨丝裂霉素C和肝素用于小梁切除术的临床疗效。方法：采用随机对照的方法，将青光眼患者90例（150眼）分为丝裂霉素组和肝素点眼组，各75眼，行标准小梁切除术。丝裂霉素组在术中一次性应用丝裂霉素C，浓度为0.2～0.4mg/ml,　2～4min；肝素组术后用5％肝素滴眼液点眼。随访观察6个月。结果：两组的完全成功率和条件成功率均高于标准小梁切除术，两组之间的成功率差异无统计学意义（P>0.05）。结论：在小梁切除术中应用丝裂霉素C，或术后应用肝素，均能提高手术成功率，长期保留功能性滤过泡。

A comparison of intra-operative mitomycin C and post-operative heparin in trabeculectomy

Objective： To explore the effect of intra-operative mitomycin C and post-operative heparin in trabeculectomy for glaucoma. Methods: One hundred and fifty eyes of ninety patients were randomly divided into the mitomycin C group and the heparin group. Mitomycin C at 0.2-0.4 mg/ml was subjected to patients of the former group for 2-4min, and 5% heparin was used in patients of the later group. Results: During a follow-up of 6 months, the success rate of the two groups was both higher than that of the standard trabeculectomy group. The difference between the two groups was not significant（P>0.05）.　Conclusion： Both intra-operative mitomycin C and post-operative heparin can improve the success rate and regain the functional bleb for a long time.