Deletions of 17p and p53 mutations in preneoplastic lesions of the lung. |
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Authors: | G Sozzi M Miozzo R Donghi S Pilotti C T Cariani U Pastorino G Della Porta M A Pierotti |
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Affiliation: | Division of Experimental Oncology A, Istituto Nazionale Tumori, Milano, Italy. |
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Abstract: | Cytogenetic and p53 mutation analysis in two cases of severe dysplasia of the bronchial epithelium in lung cancer patients and p53 immunostaining in a third one are reported. The finding of both chromosomal deletions of 17p and p53 mutation indicates that these changes may take place early in the process of lung carcinogenesis. |
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