辛伐他汀对短暂性脑缺血发作患者颈动脉粥样硬化斑块和血脂影响的研究

目的:观察辛伐他汀对短暂性脑缺血发作(TlA)患者颈动脉粥样硬化斑块和血脂水平的影响及临床疗效。方法:66例有颈动脉粥样硬化斑块的TIA患者随机分为辛伐他汀组(简称他汀组)和对照组:他汀组口服辛伐他汀和阿斯匹林6个月,对照组仅口服阿斯匹林,治疗前、后进行颈动脉超声检查,观察颈动脉内中膜厚度(IMT)、动脉粥样硬化斑块面积,检测血脂水平,比较治疗6个月内两组患者脑血管事件的发生率。结果:治疗后他汀组血胆固醇、低密度脂蛋白、甘油三酯水平比治疗前明显下降,高密度脂蛋白水平明显升高(均P<0.01);颈动脉IMT变薄及斑块面积减少,与对照组比较差异均有显著性(P<0.05);他汀组脑血管事件的发生率为9.09%,对照组为21.21%,两组间差异无显著性(P>0.05)。结论:辛伐他汀不仅有调整血脂的作用,还具有抗脂质氧化、保护血管内皮等多种作用,并能消除或稳定TIA患者的颈动脉粥样硬化斑。

Effects of simvastatin on atherosclerotic plaque of carotid and blood lipid level of patients with transient ischemic attack

Objective:To observe the effects of simvastatin on atherosclerotic plaque of carotid and blood lipid level of patients with transient ischemic attack(TlA) and clinical efficacy.Methods:Sixty-six cases of patients having carotid atherosclerosis and TIA were randomly divided into trial group and control group.Trial group took simvastatin with aspirin orally for six months,the control group only aspirin orally.The ultrasonic examination of carotid artery intima and media thickness(IMT),atherosclerosis area and determination of blood lipid levels before and after treatment for both groups.The cerebral vascular incident rates were compared within six months between two groups.Results:After treatment trial group significantly decreased the levels of blood cholesterol,low-density lipoprotein and triglyceride levels and increased high-density lipoprotein level significantly(all P<0.01).The ultrasonic examination showed thinning of carotid IMT and reducing of plaque area significantly compared with the control group(P<0.05).The cerebral vascular incident rates were 9.09 % and 21.21 % for trial group and control group respectively.There was no significant difference between the two groups(P>0.05).Conclusion:Simvastatin can not only adjust lipids level,but also has th effects of anti-lipid oxidation,protecting vascular endothelium and can eliminate or stabilize carotid atherosclerotic plaque of the patients with TIA.