| 血管内皮细胞上钙通道与氯通道功能研究进展 |
| |
| 引用本文： | 任京力,关永源.血管内皮细胞上钙通道与氯通道功能研究进展[J].南方医科大学学报,2003,23(11):1233-1236. |
| |
| 作者姓名： | 任京力 关永源 |
| |
| 作者单位： | 中山大学基础医学院药理教研室,广东,广州,510080 |
| |
| 基金项目： | 国家自然科学基金(30271503)，广东省自然科学基金团队项目CMB(00-730)，及国家科技部攀登计划(国科基字[1999]045)~~ |
| |
| 摘 要： | 血管内皮细胞属于非兴奋性细胞,覆于血管腔内表面,其胞浆膜富含离子通道,构成其独特的信号传导功能的物质基础,本文综述了近年来有关内皮细胞上钙离子和氯离子通道在内皮细胞功能中的角色的研究,以期能够进一步探讨心血管疾病与离子通道功能异常之间的关系。
|
| 关 键 词： | 钙通道 氯通道 血管内皮细胞 受体 |
| 文章编号： | 1000-2588(2003)11-1233-04 |
| 修稿时间： | 2003年6月11日 |
Progress in research on the functions of calcium and chloride channels in vascular endothelial cells |
| |
| REN Jing-Li,GUANG Yong-yuan.Progress in research on the functions of calcium and chloride channels in vascular endothelial cells[J].Journal of Southern Medical University,2003,23(11):1233-1236. |
| |
| Authors: | REN Jing-Li GUANG Yong-yuan |
| |
| Institution: | REN Jing-Li,GUANG Yong-yuanDepartment of Pharmacology,Zhongshan Medical College,Sun Yat-sen University,Guangzhou 510080,China |
| |
| Abstract: | Endothelial cells (EC) lining the inner lumen of the blood vessels are rich in ion channels that constitute the basis of a unique signal transduction function of the cells. The abundance of calcium and chloride channels in the plasma membrane of these nonexcitable cells has raised questions in regard to their functional roles. This review presents evidence for the involvement of these channels in the endothelial cell functions, in an attempt to further explore the relationship between cardiovascular diseases and functional abnormalities of the ion channels. |
| |
| Keywords: | calcium channel chloride channel vascular endothelium receptor |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
