DASRR程序治疗131例绝经后骨质疏松症妇女的5年临床研究

目的：观察DASRR程序治疗方案长期治疗绝经后骨质疏松症的疗效。方法：131例绝经后骨质疏松症患，用DASRR方案按程序先用二膦酸盐2周（羟乙膦酸钠）或4周（阿仑膦酸钠），以抑制骨吸收活动；接着用氟化物1个月，以刺激骨形成；再用活性维生素D3及钙剂1个月以加强成骨，停药1个月自发诱导下一个骨代谢周期，再按上述程序重复周期，结果：通过2－12个重复程序的治疗，骨密度（BMD）多呈明显上升趋势，其中腰椎增加13．41％（P＜0．05），双髋部平均BMD增加9．36％（P＜0．05）；骨折率逐年降低，结论：DASRR程序长期治疗绝经后骨质疏公症能更显增加腰椎和髋部BMD，降低新骨折率。

Five-year clinical study of DASRR programmed therapy of 131 postmenopausal osteoporotic women

Objective To investigate long|term effect of DASRR programmed regime on postmenopausal osteoporotic women. Methods 131 osteoporotic women were subjected to the DASRR scheme.It began with bisphosphonate for 2 weeks(etidronate) or 4 weeks (alendronate) in order to depress bone resorptive activity,followed by fluoride for 1 month to stimulate bone formation,then vitamin D 3 combined with calcium to strengthen the bone mineralization and bone formation for 1 month,and then the medication stopped for 1 month to naturally initiate the next bone metabolic cycle. Results After 2 to 12 repeated courses(8 48 months),the bone mineral density(BMD) in the majority of patients increased significantly.Lumbar and mean both hip BMD increased 13^41% and 9^36% ( P <0 05) respectively by year 4.Fracture rates decreased year by year. Conclusion Lumbar and hip BMD increased and fracture rates decreased more significantly under long|term DASRR programmed scheme in postmenopausal osteoporotic women.;