Efficacy of single-dose pegfilgrastim after chemotherapy for the mobilization of autologous peripheral blood stem cells in patients with malignant lymphoma or multiple myeloma |
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| Authors: | Kroschinsky Frank Hölig Kristina Platzbecker Uwe Poppe-Thiede Kirsten Ordemann Rainer Blechschmidt Matthias Oelschlaegel Uta Schaich Markus Hänel Mathias Bornhäuser Martin Ehninger Gerhard |
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| Institution: | 1st Medical Department, University Hospital Dresden, Dresden, Germany. kroschinsky@mk1.med.tu-dresden.de |
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| Abstract: | BACKGROUND: A single injection of pegfilgrastim has been shown to be equivalent to daily filgrastim in enhancing neutrophil recovery after chemotherapy, whereas the experiences with pegfilgrastim in mobilization of peripheral blood progenitor cells (PBPCs) are limited. STUDY DESIGN AND METHODS: Forty unselected patients with lymphoma or multiple myeloma were treated with different chemotherapy regimens followed by 6 mg of pegfilgrastim for mobilization of autologous PBPCs. Patients with an inadequate mobilization (blood CD34+ cells
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