Refractory psychotic symptoms in a patient with homozygous sickle cell disease: a 24-month follow-up |
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| Authors: | Gomes de Alvarenga Pedro Zanetti Marcus Vinicius Elkis Hélio |
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| Affiliation: | Department &; Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil |
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| Abstract: | The present report describes a case of a 33-year old male patient with homozygous sickle cell disease (SCD) with comorbid psychotic symptoms. The systematical evaluation revealed an intimate association between acute SCD complications, associated with hematological abnormalities, and psychotic symptoms worsening. Clozapine was effective in controlling psychotic symptoms refractory to previous antipsychotic trials. |
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| Keywords: | BPRS, Brief Psychiatric Rating Scale CGI, Clinical Global Impression Scale DSM-IV, Diagnostic and Statistical Manual of Mental Disorders 4th Edition g/dL, grams per deciliter Hgb, hemoglobin Ht, hematocrit IB, indirect bilirubin levels mg/day, milligrams per day mg/dL, milligrams per deciliter MRI, Magnetic resonance imaging SCD, sickle cell disease SPECT, Single photon emission computed tomography [99mTc] |
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