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In vivo growth of a bioengineered internal anal sphincter: comparison of growth factors for optimization of growth and survival
Authors:Eiichi A. Miyasaka  Shreya Raghavan  Robert R. Gilmont  Krittika Mittal  Sita Somara  Khalil N. Bitar  Daniel H. Teitelbaum
Affiliation:(1) Section of Pediatric Surgery, Department of Surgery, University of Michigan, Mott Children’s Hospital F3970, Ann Arbor, MI, 48109-0245, USA;(2) GI Molecular Motors Lab, Department of Pediatrics, Gastroenterology, University of Michigan, Ann Arbor, MI 48109-0245, USA;
Abstract:

Purpose  

Our laboratory has developed and implanted a novel bioengineered internal anal sphincter (IAS) to treat anal incontinence. Fibroblast growth factor-2 (FGF-2) has been used in mice; however, the optimal growth factor for successful IAS implantation is unclear. This study compares several growth factors in order to optimize IAS viability and functionality.
Keywords:
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