原发性肝癌患者外周血细胞和体液免疫反应变化

本文对原发性肝细胞癌(HCC)外周血白细胞、淋巴细胞及其亚群数量和淋巴细胞转化率、血清IgG、IgA、IgM、C_3、循环免疫复合物(CIC)进行了测定。并与正常人组和肝硬化组进行了分组对比研究。结果表明,HCC病人外周血白细胞、淋巴细胞、T淋巴细胞总量无明显变化,但Ea玫瑰花形成细胞和淋巴细胞转化率明显降低。血清IgG、IgA、IgM、C_3较正常对照组显著升高。Ⅲ期肝癌组血清免疫球蛋白、C_3,CIC阳性率高于肝硬化组(P<0.01)。肝癌病人外周血细胞,体液免疫指标变化与病期有关。动态观察病人细胞、体液免疫指标有助于临床判断病情、正确选择综合治疗方案。

CELLULAR AND HUMORAL IMMUNE RESPONSE CHANGES IN PRIMARY LIVER CANCER

In the present study, leucocytes, lymphocytes and various lymphocyte subsets, as defined by mixture rosette test, serum IgG, IgA, IgM, C3 and circulating immune complex (CIC) in peripheral blood were investigated in 117 patients with hepatoce-llular carcinoma (HCC). A compared analysis was also done among HCC, cirrhosis snd normal control group.The results indicate that leucocytes, lymphocytes and T lymphocytes did not asignificantly change, as compared with normal control group.However, Ea rosette-iorming cells and lymphocyte transformation rate were obviously decreased and serum fmmunoglobulins, C3 and ClC positive rate were markedly increased in HCO with Itage III as compared with cirrhosis group.The changes of cellular and humoral immune response in HCC correlated with clinical disease course of patients with HCC.To observe the cellular and humoral immune changes in HCC is useful for evaluating mmunity of patients and selecting correctly immunotherapy.