Cystatin C相关方程在慢性肾脏病患者的应用评价

目的:评价血清半胱氨酸蛋白酶抑制剂-C(Cys C)相关方程在慢性肾脏病(CKD)患者肾小球滤过率(GFR)计算中的临床应用价值.方法:选取179例慢性肾脏病患者,运用MDRD方程、MDRD简化方程、Hoek方程、2006年中华医学会肾脏病学分会推荐的两个方程计算GFR,与99mTc-DTPA肾动态显像测得的GFR相比...

Cystatin-C Based Equations for Estimation of Glomerular Filtration Rate in Patients with Chronic Kidney Disease

Objective: To evaluate the clinical application value of the serum Cystatin-C(Cys C) based equations in calculating glomerular filtration rate(GFR) for patients with chronic kidney disease.Methods: A total of 179 patients with chronic kidney disease were selected,and patients' glomerular filtration rate(GFR) was calculated with MDRD equation,simplified MDRD equation,Hoek equation and equations(c-cGFR1,c-cGFR2) recommended by Chinese Society of Nephrology in 2006.These values were compared with the GFR value measured by 99mTc-DTPA renal dynamic imaging examination(sGFR).Results: The results of GFR calculated by the different equations and sGFR were significantly positively correlated,moreover,the results of c-c GFR2 had a higher correlation.Bland-Altman analysis shows that the results of simplified MDRD equation had the highest consistency.Conclusion: Cystatin C as a variable markers of GFR calculated using the second equation recommended by Chinese Soctely of Nephrology in 2006(c-cGFR2) has a higher correlation and consistency with GFR measured by 99mTc-DTPA renal dynamic imaging examination.It can be used to calculate GFR clinically in patients with chronic kidney disease.