免疫营养剂对胃癌癌前病变的调理作用

目的:研究免疫营养制剂对大鼠胃癌癌前病变阶段的影响.方法:制造大鼠胃癌癌前病变的模型,90只大鼠随机分为对照组、模型组和实验组,模型组采用普通的饲料喂养,实验组在普通的饲料喂养的基础上添加免疫加强营养制剂瑞能(120 ml/(kg·d)].分别在造模成功后4,8,12周显微镜下观察鼠胃黏膜的变化,AgNOR染色观察细...

Effects of Immunonutrition in Precancerous Lesions of Gastric Cancer in Rats

Objective: To investigate the effect of immunonutrition formula precancerous lesions of gastric cancer in rats. Methods: The rats model with precancerous lesions of gastric cancer was established by MNNG, and 90 rats were randomized into experimental group, model group and control group. Animals in model group were fed with common diets, the experimental group were fed with an enteral diet supplemented with immunonutrition formula (120 ml/\kg\5d\]). The changes of the gastric mucosa were observed under microscope after 4, 8, and 12 weeks respectively. The levels of blood IgG, IgA, IgM, CD3+,CD4+, and CD8+, as well as AgNOR positive cells counting were examined. Results: In model group, gastric mucosa got thin and atrophied, and intestinal metaplasia were seen, while in experimental group, the mucosa showed no changes. The immune function of rats with precancerous lesions of gastric cancer was inhibited, IgA and IgM levels were significantly reduced, and the ratio of CD4+/CD8+ T-cell decreased (all P<0.05). After feeding with immunonutritions for 12 weeks, the level of IgA and IgM resumed normal, the radio of CD4+/CD8+ raised, and the AgNOR positive cells counting decreased (all P<0.01). Conclusion: Immunonutritions could effectively reverse the precancerous lesions in gastric carcinoma and its mechanisms of reversion probably relate to the enhance immunological function and nutritional status.