64层螺旋CT评价动脉粥样硬化病变的实验研究

目的:探讨64层螺旋CT血管造影(CTA)检查对兔主动脉粥样硬化早期病变的诊断价值.方法:通过高脂饮食建立15只新西兰大耳白兔的动脉粥样硬化动物模型.分别进行CT血管造影检查,并与病理结果进行对照研究,测量其敏感度.结果:高脂饮食2个月后实验兔主动脉开始出现病变,5个月后所有实验兔主动脉均发现粥样硬化斑块,CTA检查对...

Experimental Study of 64-Slice CT Angiography for the Evaluation of Atherosclerotic Plaques

Objective: To explore the diagnostic value of 64-slice spiral CT angiography (CTA) in the early atherosclerotic plaques on New Zealand rabbits. Methods: Fifteen New Zealand white male rabbits induced by atherogenic diet were served as the experimental models of atherosclerosis. CTA was performed in all rabbits and the results were compared with pathological findings. Results: The lipid-rich core could be observed in two months after high cholesterol diet, after five months, all rabbits had atherosclerotic plaques. It is hard for CTA to find out pristine plaques, but when these plaques were obviously thickened or became fibrous plaque, all could be found by CTA. The sensitivity of diagnosis was 62.1%. Conclusion: 64-slice spiral CT angiography is feasible, accurate, and reliable, and it has special value in diagnosing atherosclerosis, although it has some limitations in early lesions.