半剂量光动力治疗中心性浆液性脉络膜视网膜病变患者黄斑光相干断层扫描二维和三维图像的定量比较

目的:观察中心性浆液性脉络膜视网膜病变(CSC)患者半剂量光动力治疗(PDT)前后黄斑光相干断层扫描(OCT)二维和三维图像的变化特点,比较二维图像中神经上皮层厚度指标和三维图像中神经上皮层容积指标在治疗前后与视力的相关性以及在诊断中的灵敏度和特异性.方法:选取经间接眼底镜、眼底荧光素血管造影(FFA)和OCT确诊的C...

Quantitative Comparison Between Two-Dimensional and Three-Dimensional Macular Optical Coherence Tomography in the Central Serous Chorioretinopathy Treated by Photodynamic Therapy with Half Dose

Objective: To explore the characteristic of two-dimensional imaging and three-dimensional imaging of macular optical coherence tomography (OCT) in the central serous chorioretinopathy (CSC) treated by photodynamic therapy (PDT) with half dose, and to study the correlation between visual acuity and imaging feature, as well as the sensitivity and specificity of two-dimensional imaging and three-dimensional imaging of macular OCT in diagnosis of CSC. Methods: Twenty eyes of 19 patients with CSC determined by indirect ophthalmoscope, fundus fluorescence angiography (FFA) and OCT were involved in this study. Visual acuity and OCT examination were performed in all subjects before and one month after PDT with half dose. Results: The thickness of retinal neuroepithelial layer in two-dimensional imaging of OCT and the volume of retinal neuroepithelial layer in three-dimensional imaging of OCT were declined significantly in one month after PDT with half dose, meanwhile, visual acuity got notable improving. There was no significant correlation between the thickness and the volume of retinal neuroepithelial layer and visual acuity before PDT in CSC patients, while they had notable correlation in a month after PDT. Before PDT, area under receiver operating characteristics curve (AUC) of the thickness of retinal neuroepithelial layer in two-dimensional imaging of OCT and the volume of retinal neuroepithelial layer in three-dimensional imaging of OCT were respectively 0.818 and 0.914. The sensitivity and the specificity of the former were 85% and 65%, and those of the latter were 85% and 100%. One month after PDT, AUC of the thickness was 0.175, but the other one had no statistical meaning. The sensitivity and the specificity of the thickness were 15% and 100%. Conclusion: PDT with half dose verteporfin might be an effective treatment for CSC. The change of the volume of retinal neuroepithelial layer in three-dimensional imaging of OCT has a better reflection in the illness condition and treatment result of CSC than the thickness in two-dimensional imaging.