颈动脉内膜中层增厚患者血清同型半胱氨酸变化的研究

目的:探讨血清同型半胱氨酸(Hcy)与颈动脉内膜中层厚度(IMT)、斑块特征的相关性.方法:选择200例患者,采用高分辨血管外超声法检测IMT及粥样斑块;根据IMT及斑块情况,分为内膜正常组、内膜弥漫性增厚组、稳定性斑块组、不稳定性斑块组.用酶联免疫吸附法方法测定各组血清中Hcy浓度,分析超声结果与血清Hcy浓度的关系...

Changes of Homocysteine in Patients with Increased Carotid Intima-Media Thickness

Objective:To investigate the relationship between homocysteine(Hcy) and carotid intima-media thickness(CIMT).Methods:Two hundred patients were selected.High-resolution ultrasound was used to scan carotid and brachial arteries of all patients in order to check and measure CIMT,plaques of carotid arteries,and diameter of brachial arteries at rest.Patients were divided into four groups:normal carotid intima group,diffused proliferative carotid intima group,stable plaque group and unstable plaque group.Serum levels of Hcy were determined with immunological method.The relationship between the results measured by ultrasound instrument and the concentrations of Hcy was analyzed.Results:The serum levels of Hcy in proliferative carotid intima group were higher than in the normal carotid intima group(P<0.05).The serum levels of Hcy in unstable plaque group and in stable plaque group were higher than those of diffused proliferative carotid intima group(P<0.05).The serum levels Hcy in the unstable plaque group were higher than in stable plaque group(P<0.05).Conclusion:The increased concentrations of hcy were closely correlated with the increment of carotid intima-media thickness and the unsteady state of plaque.