| 生物活性负压封闭吸引材料的生物学评价 |
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| 引用本文： | 付涛,喻爱喜,吴刚,祝少博,宋九宏.生物活性负压封闭吸引材料的生物学评价[J].武汉大学学报(医学版),2011,32(2):183-186. |
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| 作者姓名： | 付涛 喻爱喜 吴刚 祝少博 宋九宏 |
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| 作者单位： | 1. 武汉大学中南医院显微骨科,湖北,武汉,430071
2. 武汉维斯第医用科技有限公司,湖北,武汉,430023 |
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| 基金项目： | 武汉市科技局科研基金赍助项目，湖北省自然科学基金重点项目，武汉大学博士研究生自主科研项目 |
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| 摘 要： | 目的:对制备的生物活性聚乙烯醇/壳聚糖复合泡沫材料进行生物学评价,为临床应用提供实验依据.方法:对该材料进行细胞毒性试验、急性全身毒性试验、溶血试验、皮肤刺激试验、热源试验和微核试验.结果:该材料的细胞毒性为Ⅰ级,对细胞生长和增殖无明显抑制作用,无急性全身毒性反应,无溶血反应,无皮肤刺激性,无热源反应,无致突变作用.结...
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| 关 键 词： | 生物活性 负压封闭引流技术 壳聚糖 生物相容性 细胞毒性 |
Preparation and Biological Evaluation of the Bioactivity Vacuum Sealing Materials |
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| FU Tao,YU Aixi,WU Gang,ZHU Shaobo,SONG Jiuhong.Preparation and Biological Evaluation of the Bioactivity Vacuum Sealing Materials[J].Medical Journal of Wuhan University,2011,32(2):183-186. |
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| Authors: | FU Tao YU Aixi WU Gang ZHU Shaobo SONG Jiuhong |
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| Abstract: | Objective: To evaluate the bio-safety of the prepared PVA/CS composite foam materials with biological activity in order to provide experiment basis for clinical application.Methods: The materials were evaluated by cytotoxicity test,acute systemic toxicity test,hemolysis test,skin irritation test,pyrogen test and micro nucleus test.Results: The cytotoxicity score of was grade 0,and the growth and proliferation of the cultured cells were not significantly inhibited.There were no acute systemic toxicity reaction,no hemolytic reaction,no skin irritation,no pyrogen reaction and no gene mutation.Conclusion: The materials have excellent bio-safety and show a prosperous future of clinical application. |
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| Keywords: | Biological Activity Vaccum Sealing Drainage Chitosan Biocompatibility Cyto Toxicity |
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