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| 蝙蝠葛诺林碱对小鼠软脑膜微循环障碍的改善作用 | |
| 引用本文： | 张晋,杨磊,郭莲军. 蝙蝠葛诺林碱对小鼠软脑膜微循环障碍的改善作用[J]. 武汉大学学报(医学版), 2011, 32(1): 36-39 |
| 作者姓名： | 张晋 杨磊 郭莲军 |
| 作者单位： | 1. 湖北省中山医院神经内科,湖北,武汉,430033 2. 华中科技大学同济医学院附属协和医院麻醉科,湖北,武汉,430022 3. 华中科技大学同济医学院基础医学院药理学系,湖北,武汉,430030 |
| 摘 要： | 目的:探讨蝙蝠葛诺林碱对小鼠软脑膜微循环障碍的改善作用.方法:制备开放式颅窗,采用B12000图像分析系统监测小鼠软脑膜微循环,并在软脑膜局部滴加去甲肾上腺素复制微循环障碍模型,观察局部给予蝙蝠葛诺林碱对小鼠软脑膜微小血管管径和开放数目的影响.结果:不同剂量的蝙蝠葛诺林碱对去甲肾卜腺素所致的软脑膜微动脉和微静脉收缩均有... |
| 关 键 词： | 蝙蝠葛诺林碱 软脑膜微循环 小鼠 |
Effects of Daurinoline on Microcirculation of Cerebral Pia Mater in Mice |
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| ZHANG Jin,YANG Lei,GUO Lianjun. Effects of Daurinoline on Microcirculation of Cerebral Pia Mater in Mice[J]. Medical Journal of Wuhan University, 2011, 32(1): 36-39 | |
| Authors: | ZHANG Jin YANG Lei GUO Lianjun |
| Abstract: | Objective: To investigate the effect of daurinoline on cerebral pia mater microcirculation in mice. Methods: An open cranial window was performed and microcirculation disturbance state was established by means of administering noradrenaline on the cerebral pia mater. The effect of daurinoline was observed from the changes of the diameters and numbers of the arterioles and venules. Results: Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline. Conclusion: It suggests that daurinoline would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury. |
| Keywords: | Daurinoline Cerebral Pia Mater Microcirculation Mice |
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