封闭负压引流对创面组织氧含量的影响

目的:探讨封闭负压引流(VSD)下创面的组织氧含量变化,为VSD在特殊创面中的应用提供一定的理论支持.方法:24例皮肤软组织缺损的患者:其中有12例采用VSD治疗(VSD组),其余12例采用常规换药治疗(对照组).治疗1周后,分别对这两组24例病例测定创面局部组织液氧分压(PiO2)、乳酸脱氢酶(LDH)及琥珀酸脱氢酶...

Effect of Vacuum Sealing Drainage on Oxygen Content of Wound Tissue

Objective:To study the changes of oxygen content in vacuum sealing drainage(VSD) wound tissue.Methods:Twenty-four cases of skin and soft tissue defects were treated with VSD(VSD group,n=12) or with traditional dressing(control group,n=12).After one week,local tissue fluid partial pressure of oxygen(PiO2),levels of lactate dehydrogenase(LDH) and succinic dehydrogenase(SDH) were determined,and mitochondria density and morphological characteristics of cells were observed under transmission electron microscope(TEM).Results:The PiO2 and SDH levels in local tissue fluid were significantly higher while the LDH levels were lower in VSD group than in control group(all P<0.01).The mitochondria density was increased,and morphological changes under TEM were more significant in VSD group as compared with those in control group.Conclusion:Aerobic metabolism of the wound tissue treated with VSD is active and the oxygen content is rich,which is helpful for the recovery of soft tissue defects.