FIBRINOLYTIC ACTIVITY IN LUNG TISSUE FROM NEONATES WITH HYALINE MEMBRANE DISEASE |
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Authors: | H. EKELUND,M. PANDOLFI,GÖ REL Ö STBERG,A. BJERNSTAD |
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Affiliation: | Coagulation Laboratory, the Departments of Paediatrics and Pathology, University of Lund, General Hospital, Malmö, Sweden |
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Abstract: | The fibrinolytic activity of lung tissue was studied with Todd's histochemical method in a material of 29 newborn infants containing normal lungs, hyaline membrane disease, atelectasis and massive pulmonary haemorrhage. No significant difference was found between a group of hyaline membrane lungs and a group of atelectatic lungs without hyaline membranes. In one case with massive pulmonary haemorrhage the activity was high. Our findings make it questionable whether a lack of plasminogen activator in the lung of infants with hyaline membrane disease is a consistent finding and argue against an alteration of the intrapulmonary fibrinolytic system being of any major importance in the formation of the membranes. |
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Keywords: | Tissue fibrinolysis hyaline membrane disease atelectasis massive pulmonary haemorrhage newborn |
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