内源性雌激素与阿尔茨海默病的病例对照研究

目的探讨内源性雌激素与阿尔茨海默病(Alzheimer'sdiseose,AD)是否存在病因联系.方法以人群为基础进行年龄、性别匹配的病例对照研究.病例组为样本人群中确诊的全部女性AD患者共115例;对照组为符合匹配条件的全部未发生认知功能障碍者共1041名.结果自然绝经年龄对AD发病有显著影响,自然绝经年龄为47～50岁的女性,患AD的危险为绝经年龄＜47岁女性的0.672倍;绝经年龄＞50岁的女性患AD的危险则为绝经年龄＜47岁女性的0.452倍(P=0.0207).初潮年龄每增加1岁,校正的OR值为1.160(P=0.0342).结论内源性雌激素与AD可能存在病因联系.

A case-control study of endogenous estrogen and risk of Alzheimer' s disease

Objective To investigate the risk of Alzheimer's disease (AD) associated with endogenous estrogen. Methods A population based,m:n matched case control study was conducted, including 115 female AD patients identified from sample population aged 55 years or older as cases and 1 041 non cognitive impairment individuals from same population matched for age and sex as controls. Results Age at natural menopause had significant effect on AD using multivariate analysis. The odds ratio ( OR ) for AD was 0.672 for individuals whose age at natural menopause were between 47 to 50 years old, compared with individuals whose age at menopause were less than 47 years old. The OR was 0.452 for individuals whose age at menopause were more than 50 years old comparing with individuals whose age at menopause were less than 47 years old ( P = 0.020 7 ). The OR for AD increased parallel to the increase of age at menarche (adjusted OR = 1.160 for each increased year, P = 0.034 2 ). Conclusion The decrease of endogenous level in postmenopausal women might serve an etiological factor for AD.