| 异甘草酸镁对慢性乙型肝炎患者肝纤维化指标的影响 |
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| 引用本文： | 崔鹤松,陈宁. 异甘草酸镁对慢性乙型肝炎患者肝纤维化指标的影响[J]. 世界临床药物, 2008, 29(11): 670-673 |
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| 作者姓名： | 崔鹤松 陈宁 |
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| 作者单位： | 吉林省延边大学医院感染科 |
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| 摘 要： | 目的 探讨异甘草酸镁对慢性乙型肝炎患者肝纤维化指标的影响.方法 选取60例慢性乙型肝炎住院患者,随机分为两组.对照组(n=24)接受一般保肝药物治疗,治疗组(n=36)在对照组基础上加用异甘草酸镁治疗,疗程均为1月,观察各组治疗前后透明质酸(HA)、层黏蛋白(LN)、Ⅳ型胶原(ⅣC)、转化生长因子-β1(TGF-β1)含量的变化情况.结果 与治疗前相比,治疗组HA、LN、ⅣC及TGF-β1含量治疗后均显著下降(P＜0.05,),而对照组上述指标无明显下降(P＞0.05).与对照组相比,治疗组各指标下降显著(P＜0.05).结论 异甘草酸镁具有降低慢性乙型肝炎患者肝纤维化指标的作用.
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| 关 键 词： | 异甘草酸镁 乙型肝炎 慢性 肝纤维化 |
The effect of magnesium isoglycyrrhizinate on indicators of hepatic fibrosis in patients with chronic type B hepatitis |
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| CUI He-Song,CHEN Ning. The effect of magnesium isoglycyrrhizinate on indicators of hepatic fibrosis in patients with chronic type B hepatitis[J]. WORLD CLINICAL DRUGS, 2008, 29(11): 670-673 |
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| Authors: | CUI He-Song CHEN Ning |
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| Affiliation: | CUI He-Song,CHEN Ning(Department of Infectious Diseases,Yanbian University Hospital,Yanji 133000,China) |
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| Abstract: | Objective To evaluate the effect of magnesium isoglycyrrhizinate on indicators of hepatic fibrosis in patients with chronic type B hepatitis.Methods 60 in-patients with chronic type B hepatitis were randomly divided into two groups.Patients in control group(n = 24) were administered conventional liver protectants while patients in treatment group(n = 36)were added magnesium isoglycyrrhizinate on the basis of control group.The treatment course were both one month.The levels of hyaluronic acid(HA), laminin(LN... |
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| Keywords: | magnesium isoglycyrrhizinate type B hepatitis chronic hepatic fibrosis |
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