| 血清乙型肝炎病毒前S1抗原对判定HBV DNA复制的临床价值 |
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| 引用本文： | 占国清,谭华炳,李芳,李儒贵,李金科. 血清乙型肝炎病毒前S1抗原对判定HBV DNA复制的临床价值[J]. 实用肝脏病杂志, 2011, 14(2): 103-105. DOI: 10.3969/j.issn.1672-5069.2011.02.006 |
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| 作者姓名： | 占国清 谭华炳 李芳 李儒贵 李金科 |
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| 作者单位： | 湖北医药学院附属人民医院肝病研究所,湖北省十堰市,442000 |
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| 摘 要： | 目的通过分析HBV Pre-S1抗原与HBeAg和HBV DNA的相关性,以探讨其在诊断HBV复制的临床价值。方法采用ELISA法、荧光定量PCR法检测450例HBsAg阳性及50例健康对照血清标本的HBV Pre-S1抗原、血清HBV标志物、HBV DNA及肝功能。结果在450例HBsAg阳性血清中,HBeAg、Pre-S1抗原和HBV DNA阳性率分别为40.0%、57.3%和61.6%;Pre-S1抗原、HBV DNA阳性率在HBeAg阴性与阳性组间差异有统计学意义（x2=84.2,x2=110.7,P〈0.01）;PreS1抗原与HBeAg和HBV DNA均存在相关性（x2=86.5x,2=272.1,P〈0.01）;Pre-S1抗原阳性组AST、ALT、TBl、γ-GT均高于阴性组（P〈0.01）;当HBV DNA拷贝数的对数值〉2.7lgcopies/ml时,Pre-S1抗原诊断HBV复制的敏感度为87.7%,特异度为91.3%,准确性为89.1%,阳性预测值为94.2%,阳性似然比为10.1,优势比为75.3,而HbeAg则分别为59.2%、90.8%、71.3%、91.1%、6.43和14.2。结论 HBV Pre-S1抗原与HBeAg和HBV DNA均有较好的相关性,可作为一项新的病毒复制的指标。
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| 关 键 词： | 乙型肝炎病毒 前S1抗原 HBeAg HBVDNA |
The relationshiop of hepatitis B virus Pre-S1 antigen to HBV replication |
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| ZHAN Guoqing,TAN Huabing,LI Fang,et al.. The relationshiop of hepatitis B virus Pre-S1 antigen to HBV replication[J]. Journal of Clinical Hepatology, 2011, 14(2): 103-105. DOI: 10.3969/j.issn.1672-5069.2011.02.006 |
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| Authors: | ZHAN Guoqing TAN Huabing LI Fang et al. |
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| Affiliation: | ZHAN Guoqing,TAN Huabing,LI Fang,et al.Department of Hepatology,People's Hospitol,Hubei Medicine College,Shiyan 442000,Hubei Province,China |
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| Abstract: | Objective To explore the clinical value of hepatitis B virus Pre-S1 antigen in the diagnosis of viral replication.Methods 450 HBsAg positive and 50 healthy control serum specimens were collected,and the Pre-S1 antigen and HBVM were detected by ELISA,HBV DNA levels by fluorescence quantitative polymerase chain reaction(FQ-PCR),and liver fuction by automatic biochemical analyzer respectively.Results The positive rates of HBeAg,Pre-S1 antigen and HBV DNA in all patients were 40.0%,57.3% and 61.6%,respectively;... |
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| Keywords: | HBeAg HBV DNA |
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