| 拉米夫定联合阿德福韦酯治疗耐药株感染慢性乙型肝炎37例临床观察 |
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| 引用本文： | 成娟,蔡文辉,施翠芬.拉米夫定联合阿德福韦酯治疗耐药株感染慢性乙型肝炎37例临床观察[J].实用肝脏病杂志,2011,14(2):114-115. |
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| 作者姓名： | 成娟 蔡文辉 施翠芬 |
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| 作者单位： | 江苏省盐城市第二人民医院感染病科,224003 |
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| 摘 要： | 目的观察拉米夫定联合阿德福韦酯治疗耐药株感染慢性乙型肝炎患者的疗效。方法耐拉米夫定慢性乙型肝炎患者11例换用阿德福韦酯,耐阿德福韦酯患者6例换用拉米夫定和耐拉米夫定28例/耐阿德福韦酯9例给予拉米夫定联合阿德福韦酯,观察治疗48周的疗效。结果在治疗48周时,拉米夫定联合阿德福韦酯组患者血清HBV DNA阴转率（76%）和ALT复常率（92%）明显高于阿德福韦（45%,73%）和拉米夫定（50%,83%）治疗患者。结论拉米夫定联合阿德福韦酯治疗耐药的慢性乙型肝炎患者,优于单用拉米夫定或阿德福韦酯治疗。
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| 关 键 词： | 慢性乙型肝炎 拉米夫定 阿德福韦酯 病毒耐药 |
Observation upon curative effect of lamivudine and adefovir combination therapy on patients with chronic hepatitis B |
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| CHENG Juan,CAI Wenhui,SHI Cuifen.Observation upon curative effect of lamivudine and adefovir combination therapy on patients with chronic hepatitis B[J].Journal of Clinical Hepatology,2011,14(2):114-115. |
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| Authors: | CHENG Juan CAI Wenhui SHI Cuifen |
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| Institution: | CHENG Juan,CAI Wenhui,SHI Cuifen.Department of Infectious Diseases,The Second People's Hospital,Yancheng224002,Jiangsu Province |
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| Abstract: | Objective To observe the effect of lamivudine and adefovir combination therapy on patients with chronic hepatitis B.Methods 11 patients tolerated lamivudine switched to adefovir,6 tolerated to adefovir switched to lamivudine,and 28 tolerated lamivudine and 9 tolerated adefovir switched to lamivudine and adefovir combination therapy.Results At the end of 48 weeks therapy,the serum HBV DNA negative rate(76%)and ALT normalization rate(92%)in combination group were much higher than in adefovir(45%,73%)or lamivu... |
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| Keywords: | Hepatitis B Lamivudine Adefovir Mutation |
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