| 交链孢酚单甲醚对人胎儿食管和胃上皮脂质过氧化的影响 |
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| 引用本文： | 张鹏,董子明.交链孢酚单甲醚对人胎儿食管和胃上皮脂质过氧化的影响[J].中国病理生理杂志,1990,6(1):36-39. |
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| 作者姓名： | 张鹏 董子明 |
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| 作者单位： | 河南医科大学病理生理学教研室
(张鹏，董子明，刘桂亭，郝慧灵，杨红艳)，河南医科大学食管癌研究室
(王念慈，苗健)，河南医科大学食管癌研究室(甄应中) |
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| 摘 要： | 本文报道食道癌高发区粮食中分离的互隔交链孢霉的代谢物交链孢酚单甲醚(AME)在体外攻击人胎儿食管及胃上皮后对相应组织脂质过氧化的影响。采用硫代巴比妥酸试验测定丙二醛含量反映脂质过氧化程度。AME可使胎儿食管及胃丙二醛含量明显升高(P<0.01),其程度与AME剂量相关,说明AME可引发这两器官上皮组织的脂质过氧化。随作用时间的延长,脂质过氧化程度愈来愈高,至4小时达高峰。食管对AME的反应较胃更强烈,提示AME有一定的器官选择性。根据本研究结果。推测AME可能是林县地区人食管癌的病因之一。
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| 关 键 词： | 食管肿瘤 致癌物 真菌 过氧化脂质 |
Effect of alternariol monomethyl ether on the lipid peroxidation in the epithelia of fetal esophagus and stomach |
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| Zhang Peng,Dong Zi-Ming. et al.Effect of alternariol monomethyl ether on the lipid peroxidation in the epithelia of fetal esophagus and stomach[J].Chinese Journal of Pathophysiology,1990,6(1):36-39. |
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| Authors: | Zhang Peng Dong Zi-Ming |
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| Institution: | Zhang Peng,Dong Zi-Ming. et al Department of Pathophysiology,Henan Medical University,Zhengzhou |
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| Abstract: | The effect of Alternariol Monomethyl Ether (AME), a suspected carcinogen in human being, on the lipid peroxidation in the epithelia of fetal esophagus and stomach was studied. The epithelia of esophagus and stomach of human fetus induced labor with water-bag were treated with AME. Lipid peroxides were measured by thiobarbituric acid test for malondialdehyde (MDA). There was a positive correlation between the values of MDA levels and AME dosaeges. It demonstrated that the lipid peroxdation could be initiated with AME. Lipid peroxidation levels were increased following treatment time elongating. The values of MDA levels in esophagus were higher than those in stomach, which were treated with the same dosaege of AME. It showed that AME had an organ selectivity. These results indicate that AME may be one of genetoxic etiological factors of esophageal carcinoma in Linxian county. |
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| Keywords: | Esophageal neoplasms Fungi Alternaria Carcinogens Lipid peroxides |
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