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| 拉米夫定治疗慢性乙型肝炎患者血清及PBMC内HBV DNA的动态变化 | |
| 引用本文： | 柯昌征,陈悦,龚作炯,王明春,李东,朱琳,刘莉,周作华. 拉米夫定治疗慢性乙型肝炎患者血清及PBMC内HBV DNA的动态变化[J]. 中西医结合肝病杂志, 2004, 14(4): 197-199 |
| 作者姓名： | 柯昌征 陈悦 龚作炯 王明春 李东 朱琳 刘莉 周作华 |
| 作者单位： | 1. 武汉大学人民医院感染科,湖北武汉,430060 2. 郧阳医学院附属太和医院感染科 3. 郧阳医学院附属太和医院检验科 |
| 基金项目： | 武汉大学创新基金资助(No:301270054) |
| 摘 要： | 目的 :研究拉米夫定对慢性乙型肝炎 (慢乙肝 )患者血清及PBMC内HBVDNA的抑制作用。方法 :应用荧光定量PCR方法动态观察 72例拉米夫定治疗组和对照组患者血清及PBMC内HBVDNA的含量变化。结果 :治疗组血清HBVDNA在治疗 6周时 ( 2～ 8周 ) 2 1例转阴 ,PBMC中HBVDNA在治疗 16周 ( 8～ 2 4周 )时 17例转阴。结论 :拉米夫定对慢乙肝患者血清HBVDNA有较强的抑制作用 ,起效快 ,同时 ,随着治疗时间的延长 ,对PBMC内HBVDNA也有一定的抑制作用 ,但滞后于血清中HBVDNA的转阴 |
| 关 键 词： | 拉米夫定/治疗应用 肝炎病毒 乙型 脱氧核糖核酸 外周血单个核细胞 |
| 修稿时间： | 2004-05-11 |
Dynamic Changes of Hepatitis B Virus DNA in Serum and in Peripheral Mononuclear Cells in the Patients with Lamivudine Therapy |
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| KE Changzheng,CHEN Yue,GONG Zuojiong,et al.. Dynamic Changes of Hepatitis B Virus DNA in Serum and in Peripheral Mononuclear Cells in the Patients with Lamivudine Therapy[J]. Chinese Journal of Integrated Traditonal and Western Medicine on Liver Diseases, 2004, 14(4): 197-199 | |
| Authors: | KE Changzheng CHEN Yue GONG Zuojiong et al. |
| Affiliation: | KE Changzheng~1,CHEN Yue~2,GONG Zuojiong~1,et al.1 Department of Infectious Diseases,Renmin Hospital,Wuhan University |
| Abstract: | Objective:To study the dynamic changes of hepatitis B virus DNA in serum and in peripheral mononuclear cells in the patients with Lamivudine therapy.Methods:Seventy-two patients with chrnic hepatitis B virus (HBV) infection were investigated for HBV DNA both in serum and in peripheral blood mononuclear cells(PBMCs) by fluorescence quantitative polymerase chair reation(PCR),during and after Lamivudine treatment.Results:HBV DNA both in serum and in PBMCs, become negative in 21 cases and 17 cases respectively during Lamivudine treatment. The average conversion period of HBVDNA was 6w (2-8w) in serum and 16w (8-24w) in PBMCs. Conclusion:Lamivudine has remarked inhibitory effect on HBV DNA both in serum and in PBMCs. The inhibitoty effect on HBV DNA in PBMCs was sloowe than in serum. |
| Keywords: | Lamivudine/Therapeutic Use Hepatitis B Virus(HBV) DNA Peripheral Blood Mononuclear Cells(PBMCs) |
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