Surdités auto-immunes : bases pathogéniques et applications thérapeutiques |
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Authors: | B. Hervier P. Bordure A. Masseau C. Calais C. Agard M. Hamidou |
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Affiliation: | 1. Service de médecine interne, CHU de Nantes–Hôtel-Dieu, place Alexis-Ricordeau, 44093 Nantes cedex, France;2. Service de chirurgie ORL et cervicale, CHU de Nantes, France |
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Abstract: | Sensorineural hearing loss may be due to an autoimmune mechanism. The mechanisms that could induce autoimmune inner ear damage are now better understood, but are not exclusive. Moreover, there is no specific immunologic test available for the diagnosis of autoimmune sensorineural hearing loss, which could also complicate the disease course of other autoimmune systemic diseases. Thus, the incidence of sensorineural autoimmune hearing loss is probably underestimated. The aim of this study was to review the experimental immunologic data in favour of an autoimmune mechanism in this subgroup of sensorineural hearing loss: humoral specific response against inner ear (autoantibodies against a transmembrane transporter) and also cellular response (against cochlin: one of the major proteins expressed in the inner ear). The aim of this review was also to focus on clinical and epidemiological human data that provide evidence for an autoimmune etiopathogeny of some sensorineural hearing loss. Therapeutic options such as immunosuppressive treatments (oral corticosteroids and other immunosuppressive drugs, such as methotrexate and anti-TNFα) are also discussed. |
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Keywords: | Surdité neurosensorielle Surdité de perception Maladies auto-immunes Auto-immunité Cochline |
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