他莫西芬对去势大鼠骨生物力学性能的影响

目的评价他莫西芬对雌激素缺乏引起的骨生物力学性能下降的预防作用。方法采用4月龄Sprague-Dawley(SD)雌性大鼠切除卵巢作动物模型,术后给予他莫西芬治疗连续12周。结果与假手术组相比去势组骨密度、股骨生物力学性质、腰椎骨形态计量指标均有显著差异;他莫西芬处理组与去势组比较,股骨骨密度、股骨最大载荷、桡度、最大应力、弹性模量显著升高,骨形态计量参数的改变均有显著性。结论他莫西芬能抑制去势引起的SD大鼠骨生物力学性能下降。

Effects of tamoxifen on biomechanical properties of bone in ovariectomized rats

Objective To evaluate the effects of tamoxifen on biomechanical properties of bone induced by depletion of estrogen. Method Bone mineral density (BMD), biomechanical properties and bone histomorphometric parameters were investigated in 4-month-old ovariectomized Sprague-Dawley (SD) rats. Administration of tamoxifen was started after ovariectomy for 4 weeks!and continued for 12 weeks.Result BMD, biomechanical properties and bone histomorophometric parameters significantly changed in OVX rats, compared with sham-operated rats. Significant increasing was found in OVX+TAM rats, compared with OVX rats, in regard to the BMD values of femoral draft, proximal femoral segment and lumbar, the bone histomorphometric parameters of L2, and the biomechanical parameters of femur such as maximum load, elastic deformation, maximum stress and elastic modulus.Conclusion Tamoxifen can inhibit bone loss and the decrease of biomechanical properties in ovariectomized SD rats.