T-lymphocyte subpopulations in peripheral blood of patients with multiple sclerosis, patients with other neurological diseases and healthy controls |
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| Authors: | J de Graaf J M Minderhoud A W Teelken |
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| Affiliation: | 1. Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, Nevada;2. Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia;3. Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California;1. Carroll School of Management, Fulton Hall 344, Boston College, 140 Commonwealth Ave., Chestnut Hill, MA 02467, USA;2. Metropolitan College, Boston University, 808 Commonwealth Ave., Boston, MA 02215, USA;3. Dyson School of Applied Economics and Management, Cornell University, 340D Warren Hall, Ithaca, NY 14853, USA;4. Dyson School of Applied Economics and Management, Cornell University, 410 Warren Hall, Ithaca, NY 14853, USA;1. National Renewable Energy Laboratory, United States;2. Electric Power Research Institute, United States;3. Argonne National Laboratory, United States;2. POLYMAT, Department of Polymer Science and Technology, Faculty of Chemistry, University of the Basque Country, PO Box 1072, 20080 Donostia-San Sebastián, Spain |
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| Abstract: | We report our results in profiling peripheral blood lymphocyte subpopulations with monoclonal antibodies in 17 multiple sclerosis (MS) patients, 22 patients with other neurological diseases (OND), and 11 healthy controls, using a blind experiment. Untreated patients with a chronic progressive MS have higher T-helper cell (OKT4+) counts and a higher ratio OKT4+/OKT8+ than other MS patients, OND or healthy controls. Two weeks after the onset of a relapse of MS there is a decreased T-helper and an increased T-suppressor cell percentage. Treatment with ACTH results in a significant increase of helper cells after 4 weeks of therapy. Patients with the lowest helper cell counts and the lowest helper/suppressor ratio show the best clinical improvement by ACTH. High OKT4+ cell percentages make a chronic progressive course of MS more probable. |
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