| 前列腺癌患者PCA3 mRNA的表达及其临床意义 |
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| 引用本文： | 刘光香,郭宏骞,李笑弓,刘铁石,张士伟,燕翔,甘卫东,曾令奇.前列腺癌患者PCA3 mRNA的表达及其临床意义[J].临床泌尿外科杂志,2008,23(9):677-680. |
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| 作者姓名： | 刘光香 郭宏骞 李笑弓 刘铁石 张士伟 燕翔 甘卫东 曾令奇 |
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| 作者单位： | 南京大学医学院附属鼓楼医院泌尿外科,南京,210008 |
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| 基金项目： | 江苏省医学重点人才项目(编号RC2007007) |
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| 摘 要： | 目的：评价PCA3在前列腺癌诊断、临床分期及Gleason评分中的临床应用价值。方法：选取2005年11月～2006年9月在我院住院的前列腺癌患者56例，其中T2期12例，T3期21例，T4（N0～3，M0～1）期23例；Gleason评分5～7分27例，8～10分29例；BPH患者23例，健康男性9例。分别获取其外周血及前列腺按摩液，采用RT—PCR方法检测两种体液标本中PCA3的表达阳性情况，使用SPSS12．0统计软件包对其结果进行分析。结果：BPH和对照组两种体液标本未见PCA3阳性表达，而PCa患者外周血标本PCA3阳性率为88．9％（48／54），前列腺按摩液标本PCA3阳性率为81．3%（39／48），差异均有统计学意义（P〈0．01）。结论：两种体液标本PCA3的阳性表达有明显的前列腺癌特异性，并且随着前列腺癌的临床分期增高，其阳性率越高，有望成为诊断前列腺癌的新肿瘤标志物和判断预后的指标。
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| 关 键 词： | 前列腺癌 PCA3 肿瘤标志物 逆转录-聚合酶链式反应 |
The expression of PCA3 mRNA in blood and in urine sediments obtained after prostatic massage of patients with prostate cancer |
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| LIU Guangxiang,GUO Hongqian,LI Xiaogong,LIU Tieshi,ZHANG Shiwei,YAN Xiang,GAN Weidong,ZENG Lingqi.The expression of PCA3 mRNA in blood and in urine sediments obtained after prostatic massage of patients with prostate cancer[J].Journal of Clinical Urology,2008,23(9):677-680. |
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| Authors: | LIU Guangxiang GUO Hongqian LI Xiaogong LIU Tieshi ZHANG Shiwei YAN Xiang GAN Weidong ZENG Lingqi |
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| Institution: | 1Department of Urology;Drum Tower Hospital;Affiliated to Medical College;Nanjing University;Nanjing;Jiangsu;210008;China |
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| Abstract: | Objectives:Prostate cancer antigen 3(PCA3) has been identified recently, which is located at 9q21-22 and overexpressed in prostatic tumors in comparison to normal prostate and benign prostatic hyperplasia. It is very essential to search for the value of PCA3 gene as a marker in diagnose of PCa and the relationship between positive expression of PCA3 gene and clinical stage of PCa. We detected PCA3 in blood and in urine sediments obtained after prostatic massage of patients with prostate cancer by reverse tr... |
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