| 罗匹尼罗中间体2-甲基-3-硝基苯乙酸的合成 |
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| 引用本文： | 李康,杨兆琪,文富华,孙平华.罗匹尼罗中间体2-甲基-3-硝基苯乙酸的合成[J].中国药房,2007,18(19):1467-1468. |
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| 作者姓名： | 李康 杨兆琪 文富华 孙平华 |
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| 作者单位： | 1. 广东药学院药科学院,广州市,510006
2. 暨南大学药学院,广州市,510632 |
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| 摘 要： | 目的:采用新方法合成罗匹尼罗中间体2-甲基-3-硝基苯乙酸。方法:以2-甲基-3-硝基苯甲醛为原料,采用环合、氧化2步反应进行制备,并用质谱鉴别。结果:制得化合物确证为罗匹尼罗中间体2-甲基-3-硝基苯乙酸,总收率73.6%。结论:本方法简便,且缩短了反应时间,提高了反应收率。
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| 关 键 词： | 罗匹罗尼 2-甲基-3-硝基苯乙酸 合成 |
| 文章编号： | 1001-0408（2007）191467-02 |
| 收稿时间： | 2007-04-26 |
| 修稿时间： | 2007-04-262007-05-28 |
Synthesis of ( 2 - Methyl - 3 - Nitrophenyl ) Acetic Acid——An Important Intermediate of Ropinirol |
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| LI Kang,YANG Zhaoqi,WEN Fuhua,SUN Pinghua.Synthesis of ( 2 - Methyl - 3 - Nitrophenyl ) Acetic Acid——An Important Intermediate of Ropinirol[J].China Pharmacy,2007,18(19):1467-1468. |
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| Authors: | LI Kang YANG Zhaoqi WEN Fuhua SUN Pinghua |
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| Abstract: | OBJECTIVE:To synthesis(2—methyl—3—nitrophenyl)acetic acid by a new method.METHODS:(2—methyl—3—nitrophenyl)acetic acid was prepared with 2—methyl—3—nitrobenzaldehyde as raw material by ring closure and oxidation,and the identification was carried out using mass spectra.RESULTS:The prepared compound was ascertained to be(2—methyl—3—nitrophenyl)acetic acid and the total yield was 73.6%.CONCLUSION:The method is simple,due to which,the reaction time has been shortened and the yields has been improved. |
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| Keywords: | Ropinirole (2—methyl—3—nitrophenyl)acetic acid Synthesis |
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