多精受精与体外受精-胚胎移植结局的关系

目的：探讨体外受精－胚胎移植（IVF－ET）过程中多精受精对IVF结局的影响。方法：回顾性分析496个IVF－ET周期、5349个卵细胞的资料，比较有多精受精与无多精受精周期的获卵数、成熟卵比例、受精率、分裂率、卵裂胚胎数、妊娠率等指标。结果：有多精受精发生的周期，成熟卵比例、受精率以及分裂率分别为67％、76．7％和95．6％，均显著高于无多精受精周期（分别为60％、60．7％和88．7％），P＜0．01。有多精受精的周期妊娠率略高于无多精受精周期（分别为25．7％和23．6％），但无统计学上的显著性差异（P＞0．05）。结论：多精受精与卵细胞对精子的接受能力有关，预示较好的IVF结局。

Correlation between polyspermy and the outcome of in vitro fertilization-embryo transfer

Objective: To explore the influence of polyspermy on IVF outcomes in in vitro fertilization and embryo transfer (IVF ET). Methods: The data from 496 IVF ET cycles and 5349 oocytes were analyzed retros pectively. A comparison of a number of fertility parameters with and without polyspermy was done. The fertility parameters were the number of oocytes retrieved, percentage of mature oocytes,fertilization rate,cleavage rate,oocytes for ET, pregnancy rate. Results: The percentage of mature oocytes, fertilization rate, cleavage rate was 67.0%, 76.7% and 95.6%,respectively( P <0.01).The pregnancy rate was higher in polyspermic fertilization cycles (25.7%)than in cycles without polyspermy(23.6%), but with no statistical significance( P >0.05). Conclusion : Polyspermic fertilization is correlated with improved oocyte receptibility to sperm and could be consi dered as an encouraging sign for the success of IVF.