| Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots： Stress, intestinal hyperpermeability and inflammation |
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| 作者姓名： | Farhadi A Fields JZ Keshavarzian A |
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| 作者单位： | Division of Digestive disease and Nutrition Rush University Medical Center Chicago IL United States,Division of Digestive disease and Nutrition Rush University Medical Center Chicago IL United States,Division of Digestive disease and Nutrition Rush University Medical Center Chicago IL United States |
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| 摘 要： | Mast cells (MC) are pivotal elements in several physiological and immunological functions of the gastro- intestinal (GI) tract. MC translate the stress signals that has been transmitted through brain gut axis into release of proinflammatory mediators that can cause stimulation of nerve endings that could affect afferent nerve terminals and change their perception, affect intestinal motility, increase intestinal hyperpermeability and, in susceptible individuals, modulate the inflammation. Thus, it is not surprising that MC are an important element in the pathogenesis of inflammatory bowel disease and non inflammatory GI disorders such as IBS and mast cell enterocolitis.
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| 关 键 词： | 嗜碱性细胞 肠道渗透性 炎性肠病 应激 综合征 肠道屏障 |
| 收稿时间： | 2007 Mar 15 |
Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: stress, intestinal hyperpermeability and inflammation |
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| Farhadi A,Fields JZ,Keshavarzian A.Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: stress, intestinal hyperpermeability and inflammation[J].World Journal of Gastroenterology,2007,13(22):3027-3030. |
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| Authors: | Farhadi Ashkan Fields Jeremy-Z Keshavarzian Ali |
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| Institution: | Division of Digestive disease and Nutrition, Rush University Medical Center, Chicago, IL, United States |
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| Abstract: | Mast cells (MC) are pivotal elements in several physiological and immunological functions of the gastro- intestinal (GI) tract. MC translate the stress signals that has been transmitted through brain gut axis into release of proinflammatory mediators that can cause stimulation of nerve endings that could affect afferent nerve terminals and change their perception, affect intestinal motility, increase intestinal hyperpermeability and, in susceptible individuals, modulate the inflammation. Thus, it is not surprising that MC are an important element in the pathogenesis of inflammatory bowel disease and non inflammatory GI disorders such as IBS and mast cell enterocolitis. |
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| Keywords: | Mast cells Intestinal permeability Stress Inflammatory bowel disease Irritable bowel syndrome Intestinal barrier |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
