| 垂体生长激素腺瘤和胚胎垂体细胞的体外分泌效应 |
| |
| 引用本文： | 白祥军,雷霆,刘睽,薛德麟.垂体生长激素腺瘤和胚胎垂体细胞的体外分泌效应[J].华中科技大学学报(医学版),2001,30(6):566-568. |
| |
| 作者姓名： | 白祥军 雷霆 刘睽 薛德麟 |
| |
| 作者单位： | 华中科技大学同济医学院附属同济医院脑外科,武汉,430030 |
| |
| 基金项目： | 国家自然科学基金资助项目(No.39670736) |
| |
| 摘 要： | 为观察垂体生长激素(GH)腺瘤细胞的体外分泌效应,选择8例垂体GH腺瘤和4例胚胎垂体,采用单层细胞培养技术,在给予生长激素释放激素(GHRH)、生长激素释放肽-2(GHRP-2)后,发现胚胎垂体细胞具有明显的分泌效应,肿瘤细胞(gsp癌基因阳性和阴性)的分泌则表现各异;而生长抑素(SMS)对二类细胞均具有明显的抑制效应.结果表明肿瘤细胞与正常垂体细胞的激素分泌途径存在差异,下丘脑对肿瘤细胞激素分泌不再有调控作用.
|
| 关 键 词： | 垂体肿瘤 生长激素 gsp癌基因 |
| 修稿时间： | 2000年4月20日 |
The Secreting Response of Growth-hormone-secreting Pituitary Adenomas and Embryo Pituitary Cells in vitro |
| |
| Bai Xiangjun,Lei Ting,Liu Kui et al.The Secreting Response of Growth-hormone-secreting Pituitary Adenomas and Embryo Pituitary Cells in vitro[J].Journal of Huazhong University of Science and Technology(Health Sciences),2001,30(6):566-568. |
| |
| Authors: | Bai Xiangjun Lei Ting Liu Kui |
| |
| Institution: | Bai Xiangjun,Lei Ting,Liu Kui et al Department of Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
| |
| Abstract: | To invesitigate the secreting response of growth hormone (GH) secreting pituitary adenomas in vitro , 8 case of GH secreting pituitary adenomas and 4 case of embryo pituitary were selected to determine the response to GH releasing hormone (GHRH), GH releasing peptide 2 (GHRP 2) and somatostain (SMS). The results showed that the embryo pituitary cells had significant secreting response, but a mixed response to GHRH and GHRP 2 was found in both gsp positive and gsp negative pitutary tumors. Both pituitary tumor and embryo pituitary showed obviously inhibitive response to SMS. It was demonstrated that there was a difference in the hormone secreting between tumor cells and normal pituitary cells. The hormone secreting of tumor cells were not regulated by hyperthalamus. |
| |
| Keywords: | pituitary tumor growth hormone gsp oncogene |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
