头孢他啶与阿奇霉素针对大肠埃希菌、肺炎克雷伯菌体外联合药敏研究

目的评价头孢他啶与阿奇霉素联合作用，对泌尿系48株大肠埃希菌、36株肺炎克雷伯菌的体外抗菌效应。方法采用琼脂稀释法测定抗菌药物单独应用和最佳组合效应时的最低抑菌浓度（MIC）值，计算体外部分抑菌浓度指数（FIC），判断联合抑菌效应。结果头孢他啶与阿奇霉素联合应用后对大肠埃希菌、肺炎克雷伯菌MIC值均无明显降低（P〉0．05），根据FIC指数分布，表现为无关作用的为60．42％和88．89％；相加作用的为31．25％，8．33oA；协同作用的为8．33％和2．78％；未发现拮抗作用。结论头孢他啶与阿奇霉素联合应用对大肠埃希菌、肺炎克雷伯菌的体外抗菌作用以无关为主。

Combined antimicrobial susceptibility test of ceftazidime and azithromycin on escherichia coli and klebsiella pneumonia

Objective To investigate the combined effect of ceftazidime with azithromycin on 48 strains of escherichia coil and 36 strains of Klebsiella pneumonia in urinary system. Methods The minimal inhibitory concentration （MIC） of the antibiotics mentioned above was determined by agar dilution method. Fractional inhibitory concentration （FIC） index was calculated for all the selected isolates with all combinations, and the activities of antibiotics alone and in combination against the selected strains were evaluated. Results The MIC of the combined antimicrobials was not reduced significantly （P〈0.01）. 60.42% and 88.89% exhibited indifference. 31.25% and 8.33% showed addition and 0% showed no antagonism, according to the result of the FIC index assay. Conclusion The activities of ceftazidime combined with azithromycin are mainly ineffective.