| 帕金森病患者脑脊液中β-内啡肽与精氨酸加压素的含量变化 |
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| 引用本文： | 何成,王德岭,潘小平,吴永麟,张新根,刘道宽,周萌. 帕金森病患者脑脊液中β-内啡肽与精氨酸加压素的含量变化[J]. 中国神经精神疾病杂志, 1992, 0(1) |
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| 作者姓名： | 何成 王德岭 潘小平 吴永麟 张新根 刘道宽 周萌 |
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| 作者单位： | 上海医科大学基础医学部化学教研室神经化学研究室(何成，王德岭，潘小平)，上海医科大学神经病研究所(吴永麟，张新根，刘道宽)，上海医科大学神经病研究所(周萌) |
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| 摘 要： | 我们用放射免疫法测定了22例PD患者CSF中ρ—EP和AVP的含量,以40例无神经系统疾病外科病患者作为对照。结果表明,PD患者CSF中β—EP和AVP的含量均显著低于对照组(均P<0.02)。溴隐亭治疗后,两种肽的含量有升高趋势。提示β—EP与AVP在CSF中含量变化与PD发病有密切关系。
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| 关 键 词： | 帕金森病 β-内啡肽 精氨酸加压素 |
Changes in levels of beta-endorphin and arginine vasopressin in the CSF of Parkinson's disease. |
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| He Cheng,et al.. Changes in levels of beta-endorphin and arginine vasopressin in the CSF of Parkinson's disease.[J]. Chinese Journal of Nervous and Mental Diseases, 1992, 0(1) |
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| Authors: | He Cheng et al. |
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| Affiliation: | He Cheng,et al. Laboratory of Neurochemistry,Department of Chemistry,Shanghai Medical University,Shanghai. 200030 |
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| Abstract: | The concentrations of beta-endorph-in (beta-EP) and arginine vasopressin (AVP) in the CSF of patients with Parkinson's disease and the subjects without nervous disorders (the control) were determined by radioimmunoassay.The contents of beta-EP and AVP were 44% and 39% lower than the controls (P< 0.02,P<0.02),respectively.There was an upward tendency of the two peptides in CSF after the patients were treated with bromocriptine.It was suggested that the changes in contents of beta-EP and AVP seem to play an important role in the pathogenesis of Parkinson,s di-sease. |
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| Keywords: | Parkinson's disease Beta-endorphin Arginine vasopressin |
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