| 异长春花苷内酰胺经酸催化形成喜果苷的研究(英文) |
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| 引用本文： | 孟兆青,刘文君,李赞,林蕴薇,李孟璇,安士影,丁岗,王振中,萧伟,徐进宜. 异长春花苷内酰胺经酸催化形成喜果苷的研究(英文)[J]. 中国天然药物, 2013, 0(2): 188-192 |
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| 作者姓名： | 孟兆青 刘文君 李赞 林蕴薇 李孟璇 安士影 丁岗 王振中 萧伟 徐进宜 |
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| 作者单位： | [1]江苏中康药物科技有限公司,南京210009 [2]中药制药过程新技术国家重点实验室,连云港222001 [3]中国药科大学,南京210009 |
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| 基金项目： | 国家十一五重大新药创制资助项目（Nos.2009ZX09013-379,2012ZX09102201-017）资助 |
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| 摘 要： | 目的:鉴定异长春花苷内酰胺酸催化产物的结构,并探讨其反应机理。方法:用HPLC监控异长春花苷内酰胺酸催化反应过程,采用大孔吸附树脂纯化反应产物,以MS、NMR和ROESY分析确定产物结构。结果:异长春花苷内酰胺在酸催化条件下转化生成喜果苷,其转化率为52%。结论:异长春花苷内酰胺经酸催化可转化为喜果苷,其反应机理可能与化合物立体构型的稳定性有关,该发现提供了制备喜果苷的新方法。
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| 关 键 词： | 异长春花苷内酰胺 喜果苷 酸催化 转化 |
Transformation of strictosamide to vincoside lactam by acid catalysis |
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| MENG Zhao-Qing,LIU Wen-Jun,LI Zan,LIN Yun-Wei,LI Meng-Xuan AN Shi-Ying,DING Gang,WANG Zhen-Zhong,XIAO Wei,XU Jin-Yi. Transformation of strictosamide to vincoside lactam by acid catalysis[J]. Chinese JOurnal of Natural Medicines, 2013, 0(2): 188-192 |
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| Authors: | MENG Zhao-Qing LIU Wen-Jun LI Zan LIN Yun-Wei LI Meng-Xuan AN Shi-Ying DING Gang WANG Zhen-Zhong XIAO Wei XU Jin-Yi |
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| Affiliation: | 1jiangsu Zeukov Pharmaceutical S ＆ T. lnc, Nanjing 210017, China; 2State Key Lab of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China; 3China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | AIM： To identify the structure of the acid-catalyzed product of strictosamide and explore the reaction mechanism. METHODS： The acid-catalyzed reaction process of strictosamide was monitored by HPLC, and a macroporous resin was used to purify the reaction solution. The structure of the product was confirmed by MS, NMR, and ROESY spectra. RESULTS： The acid-catalyzed transformation yield from strictosamide to vincoside lactam was 52%. CONCLUSION： The reaction mechanism of the transformation from strictosamide to vincoside lactam may be related to the stability of the three-dimensional configuration of the compound. These results offer a new way to obtain vincoside lactam from the widely distributed indole alkaloid strictosamide by acid-catalysis. |
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| Keywords: | Strictosamide Vincoside lactam Acid-catalyzed transformation |
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