| 血清白细胞介素-6测定在Graves病中的临床意义 |
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| 引用本文： | 李霞,栾树荣,耿秀英,刘晓丽,李静.血清白细胞介素-6测定在Graves病中的临床意义[J].中国综合临床,2010,26(6). |
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| 作者姓名： | 李霞 栾树荣 耿秀英 刘晓丽 李静 |
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| 作者单位： | 1. 滨州医学院附属医院,256603
2. 山东省肥城市新城医院 |
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| 摘 要： | 目的 探讨血清白细胞介素-6(IL-6)测定在Graves病患者中的临床意义.方法 用ELISA法测定75例Graves病患者的IL-6,分析IL-6与其他功能指标(如T3、T4等)、免疫指标(如TRAb)的相关性,并与健康对照组比较.结果 IL-6水平Graves病组为(1.84 ±1.58)ns/L,健康对照组为(1.28 ±0.46)ng/L,2组比较差异有统计学意义(t=2.55,P<0.05).相关分析发现,IL-6与T3(r=0.55)、T4(r=0.40)、FT4(r=0.36)、FT3(r=0.35)及TRAb(r=0.47)正相关(P均<0.05),与TSH负相关(r=0.58,P<0.05).结论 IL-6可以作为Graves病的免疫紊乱及甲状腺功能的良好评价指标.
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| 关 键 词： | Graves病 白细胞介素-6 |
The clinical value of serum IL-6 detection in patients with Graves |
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| LI Xia,LUAN Shu-rong,GENG Xiu-ying,LIU Xiao-li,LI Jing.The clinical value of serum IL-6 detection in patients with Graves[J].Clinical Medicine of China,2010,26(6). |
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| Authors: | LI Xia LUAN Shu-rong GENG Xiu-ying LIU Xiao-li LI Jing |
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| Abstract: | Objective To study the clinical value of serum FL-6 detection in patients with Graves. Methods The level of IL-6 was detected in 75 Graves patients and controls with ELISA, the correlation between IL-6, other function parameter (T3, T4, etc.) and immune indicators (TRAb) were analyzed. Results The level of IL-6 in Graves patients was(1. 84 ±1. 58) ng/L, which was significantly higher than the healthy controls(l. 28 ±0.46)ng/L (t=2.55,P<0.05).IL-6 was positive correlation with T3(r =0. 55) ,T4(r =0. 40) ,FT4(r =0. 36) , FT3(r = 0. 35)and TRAb(r = 0. 47) (P <0. 05)and was negative correlation with TSH(r= -0. 58, P < 0. 05). Conclusions IL-6 can be used as a good index of immune derangement and thyroid function disorders in Grave patients. |
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| Keywords: | Grave disease Interleukin-6 |
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