| 慢性宫颈炎活检组织中人巨细胞病毒(HCMV)DNA和C—MYC癌基因的检测及相关性研究 |
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| 引用本文： | 曲迅,朱长义,孙玉玲,邓文,孟祥金,崔正言.慢性宫颈炎活检组织中人巨细胞病毒(HCMV)DNA和C—MYC癌基因的检测及相关性研究[J].泰山医学院学报,1991(4). |
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| 作者姓名： | 曲迅 朱长义 孙玉玲 邓文 孟祥金 崔正言 |
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| 作者单位： | 泰山医学院微生物学教研室，泰山医学院微生物学教研室，泰山医学院微生物学教研室，泰山医学院微生物学教研室，山东省医科院基础所免疫室，山东省医科院基础所免疫室 |
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| 摘 要： | 宫颈癌是妇科常见的恶性肿癌之一,而慢性宫颈炎是宫颈癌的高危因素。研究表明,人巨细胞病毒(Human cytomegalovirus,HCMV)感染与宫颈癌的发生有关。并已从宫颈癌组织中鉴定出了C-myc癌基因。为了探讨HCMV感染与C-myc癌基因表达的关系,本文应用核酸杂交技术对87例慢性宫颈炎患者的宫颈活检组织进行了HCMVDNA序列和C-myc癌基因序列的检测。结果87例慢性宫颈炎患者宫颈活检组织中HCMV检出率为11％(10/87),C-myc癌基因的检出率为12％(11/87)。HCMV DNA序列阳性标本中同时C-myc癌基因阳性者有5例(5/10),77例HCMV DNA序列阳性患者中,有6例(6/77),C-myc癌基因阳性。结果提示,HCMV感染对C-myc癌基因表达可能起活化作用。
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| 关 键 词： | 宫颈炎 人巨细胞病毒 C—myc癌基因 斑点分子杂交 |
DETECTION AND CORRELATION OF HUMAN CYTOMEGALOVIRUS DNA AND C--MYC ONCOOGENE IN CHRONIC CERVICITIS |
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| Qu Xun,Zhu Changyi,Sun Yuling,Deng Wen,Meng Xiangjin,Cui Zhengyan Dept. of Microbiology,Taishan Medical College.DETECTION AND CORRELATION OF HUMAN CYTOMEGALOVIRUS DNA AND C--MYC ONCOOGENE IN CHRONIC CERVICITIS[J].Journal of Taishan Medical College,1991(4). |
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| Authors: | Qu Xun Zhu Changyi Sun Yuling Deng Wen Meng Xiangjin Cui Zhengyan Dept of Microbiology Taishan Medical College |
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| Abstract: | Cervical caner is one of the most common malignant tumors in gynecopa- thy. Chronic cervicitis is the highly risky factor of cervical cancer. The data indicated that cervical cancer was related to the infection of human cytomegalovirus (HCMV) . C-myc oncogene was detected in the tissues of cervical cancer. In this report, the sequences of HCMV DNA and C- myc oncogene were detected in 87 cases of chronic cervicitis by dot blot hybridization using HCMV DNA and C-myc oncogene probes. The results showed that the positive rates were 11% (10/87) and 12% (11/87), respectively. Both HCMV DNA and C-myc oncogene were identi- fied among the HCMV DNA positive samples in about 50% (5/10), HCMV DNA negtive but C-myc positive spamples were about 7. 88% (6/77). The results showed that HCMV might have activative effect on the expression of C-myc oncogene. |
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| Keywords: | Cervicitis Human cytomegalovirus C--myc oncogene Dot blot hybridization |
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