Variant translocations (9;11): identification of the critical genetic rearrangement |
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Authors: | B N Harris E M Davis M M Le Beau M A Bitter L S Kaminer E Morgan J D Rowley |
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Institution: | Department of Medicine, University of Chicago, Ill 60637. |
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Abstract: | The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes #9 and #11 have not been reported. We have identified such variants in two patients who had acute myelomonocytic leukemia and acute monocytic leukemia, characterized by a t(9;11;18)(p22;q23;q12) and a t(9;11;13)(p22;q23;q34), respectively. The conserved junction resulting from these rearrangements is created by the translocation of chromosomal material from 9p to 11q. |
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