某院330例急性阑尾炎围手术期抗菌药物应用分析

目的:了解某院急性阑尾炎手术患者围手术期抗菌药物的应用情况。方法:对某三级甲等中医院外科2003年1月～2006年7月急性阑尾炎手术住院患者围手术期抗菌药物的应用品种、用药频度、联合用药、应用方法等进行回顾性分析。结果:330例急性阑尾炎手术患者共应用抗菌药物6类25种,单一用药8例(占2.42%),二联用药259例(占78.48%),三联用药63例(占19.09%)。合理应用抗菌药物43例(占13.03%),不合理应用287例(占86.97%),其中术前未用抗菌药物者占61.21%。术前未用和应用抗菌药物者的平均用药时间分别为8.68d和7.53d,二者具有显著性差异(P<0.05);手术切口甲级愈合率分别为92.57%和98.44%,二者具有极显著性差异(P<0.01)。结论:该院围手术期预防性应用抗菌药物存在不合理现象,应加强监管,以提高合理用药水平。

Perioperative Use of Antibiotics for Acute Appendicitis: Analysis of 330 Cases

OBJECTIVE： To investigate the perioperative use of antibiotics in patients with acute appendicitis. METHODS： The perioperative use of antibiotics in 330 surgery patients with acute appendicitis from Jan. 2003 to July 2006 in a 3 - A grade hospital was analyzed retrospectively in respect of drug variety, DDDs, drug combination, administration etc. RESULTS： A total of 6 groups （25 kinds） of antibiotics were used in all the 330 cases, of whom, 8 （2.42%） used single kind, 259 （78.48%） used two kinds concomitantly, and 63 （19.09%） used 3 kinds concomitantly; 43 （13.03%） used antibiotics rationally, and 287 （86.92%） used antibiotics irrationally; 61.21% were not given antibiotics before operation. The average medication time for patients without preoperative use of antibiotics was 8.68 d vs. 7.53 d for those with preoperative use of antibiotics, showing significant differences between the two groups （P 〈0.05）, with the first -class healing rates being 92.57% versus 98.44%, also showing significant differences （P〈0.01） . CONCLUSION： The perioperative use of antibiotics in patients with acute appendicitis were far from perfect, therefore, it is necessary to tight control on which to facilitate the rational use level of antibiotics.