氟西汀联合小剂量奥氮平治疗难治性抑郁症疗效观察

目的 探讨氟西汀联合小剂量奥氮平治疗难治性抑郁症的临床疗效及安全性.方法 将52例难治性抑郁症患者随机分为两组,均予以氟西汀治疗,研究组在此基础上联合奥氮平治疗.于治疗前后应用汉密顿抑郁量表评定临床疗效,副反应量表评定不良反应.结果 治疗4周末起两组汉密顿抑郁量表总分减分率均呈持续性升高（P＜0.01）,研究组显著高于对照组（P＜0.05或0.01）.两组副反应量表评分及不良反应发生率比较差异无显著性（P＞0.05）.结论 氟西汀联合小剂量奥氮平治疗难治性抑郁症疗效显著,安全性高,优于单用氟西汀治疗.

Curative effect of fluoxetine plus small dose olanzapine in refractory depression

Objective To explore the efficacy and safety of fluoxetine plus small dose olanzapine in refractory depression. Methods Fifty-two refractory depression patients were randomly assigned to two groups treated with fluoxetine, on this basis research group was plus olanzapine. Efficacies were assessed with the Hamilton Depression Scale （HAMD） and adverse reactions with the Treatment Emergent Symptom Scale （TESS）. Results Score-reducing rates of the HAMD total scores of both groups heightened continuously since the end of the 4th week （P〈0.01）, that was significantly higher in research than control group （P〈0.05 or 0.01）. There were no significant group differences in the TESS score and the incidences of adverse reactions （P〉0.05）. Conclusion Fluoxetine plus small dose olanzapine has an evident effect and higher safety compared with single fluoxetine in refractory depression.