陕西省汉族人群miR-149基因多态性与缺血性脑卒中相关性研究

目的探讨陕西省汉族人群miR-149基因多态性的分布情况及其与缺血性脑卒中（ischemicstroke,IS）的关系。方法缺血性脑卒中组357例，对照组373例，应用聚合酶链反应一限制性内切酶片段长度多态性方法进行基因分型。比较各基因型和等位基因频率分布及其与缺血性脑卒中的关系。结果受试者携带CC基因型比携带TT基因型（0R（95％CI）：1．739（1．088-2．781），P=0．020]患IS的风险要高。或至少携带一个C等位基因的受试者比携带T等位基因的受试者更易患ISOR（95％CI）：1．243（1．003-1．539），P=0．046]。CC基因型患者血浆叶酸水平低于TT基因型患者。结论在汉族人群中，microRNA-149C〉T单核苷酸多态性与缺血性脑卒中有关。

Association between miR-149 Polymorphism and Ischemic Stroke of Han Population in Hanzhong of Shaanxi

Objective To investigate the distribution of miR-149 polymorphism in Han population in Hanzhong of Shaanxi and its correlation with ischemic stroke. Methods The participants in this study were divided into either a ischemic stroke group （n= 357） or a control group （n= 373）. Genotyping was conducted by using polymerase chain reaction-restriction frag- ment length polymorphism and allele frequency distribution and its correlation with ischemic stroke were compared. Results When the TT homozygote genotype was used as the reference group, the CC genotype was associated with a significantly increased risk of IS- （OR（95%CI） ：1. 739（1. 088-2. 781） ,P：0. 020.] or at least carrying one C allele than among patients carrying T allele -OR（95%CI）：1. 243（1. 003-1. 539）, P=O. 046-]. In IS patients,the CC genotype was associated with a significantly decreased plasma levels of tolate when compared to the TT genotype. Conclusion The results suggested that microRNA-149 C〉T polymorphism was significantly associated with susceptibility to ischemic stroke in Chinese popula- tion.