中枢神经系统血管外皮细胞瘤MRI表现与病理分析

目的：分析中枢神经系统血管外皮细胞瘤（HPC）的MRI特征表现,并与病理结果相对照.方法：收集经手术病理确诊的15例中枢神经系统血管外皮细胞瘤患者的资料,回顾性分析其MRI表现及病理特征.结果：15例肿瘤均位于颅内脑外,MRI表现为肿瘤大多呈分叶状,T1呈等或稍低信号,T2呈稍高信号,肿块内可见囊变坏死及流空血管,周围见轻度水肿;增强扫描后肿块实质性部分明显强化,其中2例可见“脑膜尾征”.12例患者作免疫组化显示CD34、Vim均为阳性,而EMA、CK、GFAP及S-100蛋白均为阴性,Bcl-2阳性6例;10例增殖细胞核抗原Ki-67标记阳性,其中2例为10％表达,1例为10％～15％表达.结论：中枢神经系统血管外皮细胞瘤的MRI表现有一定特征性,有助于提高其术前诊断的准确性.

MRI and pathological features of hemangiopericytoma in central nervous system

Objective：To analyze MRI features of hemangiopericytoma （HPC） and correlated with pathological findings.Methods：MRI appearances and pathological features of 15 patients with HPC confirmed by pathology were analyzed retrospectively.Results：The tumor located inside the skull and outside the brain in 15 cases.On MR imaging,the tumors showed lobulated borders,isointensity or slight hypointensity on T1WI and slight hyperintensity on T2WI with cystic degeneration,blood vessel flow void sign and slight perifocal edema.The solid parts of HPC enhanced markedly after contrast agent was injected.Dural tail sign was seen in 2 cases.Immunohistochemical examination performed in 12 cases showed CD34,vimentin expression,and epithelial membrane antigen,cytokeratin,glial fibrillary acidic protein and S-100 showed no expression,Bcl-2 was expressed in 6 cases.Proliferating cell nuclear antigen Ki-67 immunohistochemical staining was expressed in 10 cases,about 10％ expressed in 2 cases,10％～15％ expressed in 1 case.Conclusion：HPC in the central nervous system has certain MRI features,which is helpful in improving the accuracy of the preoperative diagnosis.