Lack of association between acute exposure to ionizing radiationand liver cirrhosis |
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| Authors: | Gerald B Sharp Dr PH Terumi Mizuno Toshiyuki Fukuhara Shoji Tokuoka |
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| Institution: | 1. Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan, and the National Academy of Sciences, Washington, DC, USAgsharp@niaid.nih.gov;3. Department of Radiobiology and Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima;4. Department of Pathology, Hiroshima Prefectural Hospital, Hiroshima;5. Consultant, Radiation Effects Research Foundation, Hiroshima, Japan |
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| Abstract: | Purpose: Although previous studies have shown significantly increased risks of liver cirrhosis and chronic liver disease for acute radiation exposure among survivors of the atomic bombings of Hiroshima and Nagasaki, Japan, these studies have not taken into account hepatitis B virus (HBV) infections. Because HBV is associated with both A-bomb radiation and liver cirrhosis, our goal was to investigate the relationship of acute ionizing radiation to liver cirrhosis adjusting for HBV, co-occurring primary liver cancer (PLC), and other potential confounders.Materials and methods: Using a cross-sectional design and pathology review of a cohort of Japanese atomic-bomb survivors, we found that 213 of 335 (63.6%) subjects with PLC and 55 of 776 (7.1%) subjects without PLC had cirrhosis.Results: We found no association between acute exposure to A-bomb radiation and liver cirrhosis. The adjusted odds ratio of cirrhosis per Sv liver irradiation was 0.59 (95% confidence interval: 0.27 – 1.27). Cirrhosis risks for the highest tertile of radiation exposure (mean exposure 0.7 Sv) were also not elevated (0.8, 0.26 – 2.12 and 0.2, 0.03 – 0.98 among subjects with and without PLC.Conclusions: Acute exposure to liver irradiation does not increase risks of liver cirrhosis, regardless of PLC status. |
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| Keywords: | A-bomb liver irradiation hepatitis B and C virus liver cirrhosis |
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