Chromosomal Abnormalities Induced by Iodine-125 in Mouse Germ Cells |
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| Authors: | S Lavu PP Reddy OS Reddi |
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| Institution: | 1. Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, 500016, India;2. Department of Molecular Oncology and Developmental Biology, Hoffmann-La Roche Inc., Roche Research Center, Nutley, NJ, 07110, U.S.A. |
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| Abstract: | SummarySwiss albino male mice were injected intraperitoneally with 0, 185, 370 or 555 kBq (0, 5, 10 or 15 µCi) of iodine-125 (125I). All the animals were killed on the sixtieth day and chromosomal aberrations were screened in spermatocytes at meiotic metaphase I. A significant increase in the percentage of chromosomal aberrations including translocations (0, 1·2, 1·8 and 2·3 per cent translocations in controls, 185, 370 and 555 kBq groups respectively) was recorded at all dose levels indicating the clatogenic effects of 125I in mouse spermatocytes. |
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| Keywords: | chromosomal abnormalities iodine-125 auger electrons sper-matogonia translocations |
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