Antiinflammatory activity of some medicinal plant extracts from Venezuela |
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| Institution: | 1. Department of Pharmacology, Faculty of Pharmacy, University Complutense, 28040 Madrid, Spain;2. Department of Pharmacognosy, Faculty of Pharmacy, Central University of Venezuela, Caracas D.F., Venezuela;1. Department of Pharmacognosy and Phytochemistry, Jamia Hamdard University, Hamdard Nagar, New Delhi, 110062, India;2. Dabur Bio-resource Development Department, DRDC, Ghaziabad, India;1. Laboratory of Cardiovascular Research and Integrative Pharmacology, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan;2. UMR CNRS 7213, Laboratory of Biophotonics and Pharmacology, Faculty of Pharmacy, University of Strasbourg, Illkirch, France;3. Laboratory of Electrophysiology and Cardiovascular Pharmacology, Federal University of Grande Dourados (UFGD), P.O. Box 533, 79.804-970, Dourados, MS, Brazil;4. Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam, University, Islamabad 44000, Pakistan;1. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia;2. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt;3. Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, 21589, Saudi Arabia;4. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt;1. Chemistry Department, Ambo University, P.O. Box: 19, Ambo, Ethiopia;2. Department of Industrial Chemistry, College of Natural and Applied Sciences, Addis Ababa Science and Technology University, P.O. Box: 16417, Addis Ababa, Ethiopia;3. Chemistry Department, Woldia University, P.O. Box:400, Woldia, Ethiopia;4. Department of Environment Science, Graphic Era (Deemed to be University), Dehradun, India;5. Department of Biotechnology and Life Sciences, Graphic Era (Deemed to be University), Dehradun, India;6. Department of Allied Sciences, Graphic Era Hill University, Society Area, Clement Town, Dehradun, 248002, India;7. Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt;8. Center of Drug Discovery Research and Development, Ain Shams University, Cairo, Egypt;9. Division of Research and Innovation, School of Applied and Life Sciences, Uttaranchal University, Arcadia Grant, P.O. Chandanwari, Premnagar, Dehradun, Uttarakhand-248007, India;10. School of Basic and Applied Sciences, Sanskriti University, Mathura, Uttar Pradesh-281401, India |
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| Abstract: | Six medicinal plant extracts from Venezuela, used in traditional medicine, were investigated for their anti-inflammatory potential against adjuvant-carrageenan-induced inflammation (ACII). All doses expressed here are as equivalents of dried starting plant materials (1.50 g dry plant/kg body wt.). The most interesting plant extracts were Synedrella nodiflora, and the hexane leaf extract of Bursera simaruba. In ACII, orally administered extracts (at doses 40 and 80 mg/kg, respectively), inhibited both the acute and chronic phases of this experimental model of inflammation, mainly the chronic phase. These extracts exhibited potent anti-inflammatory activity daily throughout the experiment, and were as effective as reference drugs, phenylbutazone (80 mg/kg) and indomethacin (3 mg/kg). |
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