| 非小细胞肺癌组织中C-erbB-2蛋白的表达 |
| |
| 引用本文： | 刘萍,田薇薇,梁冰. 非小细胞肺癌组织中C-erbB-2蛋白的表达[J]. 郑州大学学报(医学版), 2006, 41(5): 917-918 |
| |
| 作者姓名： | 刘萍 田薇薇 梁冰 |
| |
| 作者单位： | 郑州大学第二附属医院肿瘤科,郑州,450014;郑州大学第二附属医院肿瘤科,郑州,450014;郑州大学第二附属医院肿瘤科,郑州,450014 |
| |
| 摘 要： | 目的:探讨非小细胞肺癌(NSCLC)组织中C-erbB-2蛋白的表达.方法:应用免疫组化SP法检测10例正常肺组织和42例NSCLC组织(腺癌20例,鳞癌22例;有淋巴结转移19例;分化程度Ⅰ级12例,Ⅱ级19例;Ⅲ级11例)中C-erbB-2蛋白的表达状况.结果:42例NSCLC组织中,C-erbB-2蛋白的阳性表达率47.6%(20/42)高于正常肺组织的0/10(P＜0.05).腺癌组织中C-erbB-2蛋白的阳性表达率65.0%(13/20)高于鳞癌的31.8%(7/22)(P＜0.05).C-erbB-2蛋白表达率与NSCLC组织学分级呈正相关,有淋巴结转移者高于无淋巴结转移者(P均＜0.05).结论:C-erbB-2蛋白的检测对NSCLC患者的诊治和预后评估有积极意义.
|
| 关 键 词： | 肺肿瘤 C-erbB-2 预后 非小细胞肺癌 |
| 收稿时间： | 2005-06-10 |
| 修稿时间： | 2005-06-10 |
Expressions of C-erbB-2 protein in non-small cell lung cancer tissue |
| |
| LIU Ping,TIAN Weiwei,LIANG Bing. Expressions of C-erbB-2 protein in non-small cell lung cancer tissue[J]. Journal of Zhengzhou University: Med Sci, 2006, 41(5): 917-918 |
| |
| Authors: | LIU Ping TIAN Weiwei LIANG Bing |
| |
| Affiliation: | Department of Oncology, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014 |
| |
| Abstract: | Aim: To investigate the expression of C-erbB-2 protein in non-small cell lung cancer (NSCLC) tissue and its clinical significance.Methods:Immunohistochemical staining method was used to detect the expression of C-erbB-2 in 10 cases of normal lung tissue and 42 cases of NSCLC tissue.Results: The positive expression rate of C-erbB-2 in NSCLC tissue was higher than that of the normal lung tissue (P<0.05). The positive rate of C-erbB-2 in adenocarcinoma was 65.0%(13/20), higher than that in squamous cell carcinoma (31.8%(7/22)) (P<0.05). The expression of C-erbB-2 was positively correlated with histological grade and lymph node metastasis (P<0.05).Conclusion: The detection of C-erbB-2 protein is helpful to diagnosis, prognosis and treatment of NSCLC. |
| |
| Keywords: | lung neoplasm C-erbB-2 prognosis non-small cell lung cancer |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
