Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii. |
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| Authors: | J Huskinson-Mark F G Araujo J S Remington |
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| Affiliation: | Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, CA 94301. |
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| Abstract: | The cyst form of Toxoplasma gondii has been implicated as a cause of recrudescence of the latent infection in congenitally infected patients and in the immunocompromised host. A method was developed to evaluate the effect of drugs on the cyst form of the parasite and used to evaluate a variety of therapeutic agents. The most active compounds against the cyst form in vitro were arprinocid-N-oxide, azithromycin, and the hydroxynaphthoquinone 566C80. |
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