乳腺癌组织SULT1E1蛋白表达与临床病理学特征及预后相关性的研究

目的:探讨乳腺癌组织SULT1E1的表达,并分析其与临床病理学特征及预后因素的相关性.方法:采用免疫组织化学二步法检测129例乳腺癌组织和癌旁正常组织SULT1E1的表达情况,应用Kaplan-Meier法行单因素生存分析SULT1E1的表达与临床病理学特征及预后的关系.结果:乳腺癌组织中SULT1E1的阳性表达率(25.6％)明显低于癌旁组织(45.0％),差异有统计学意义,P＜0.05;SULT1E1的表达与乳腺癌患者年龄、肿瘤大小、淋巴结转移和病理类型以及是否有远处转移等无明显相关性,P＞0.05.Kaplan-Meier生存分析曲线显示,SULT1E1阳性表达患者的术后无复发生存率较阴性表达患者明显增高,x2=4.943,P＜0.05.结论:乳腺癌组织SULT1E1低表达者提示预后不佳,SULT1E1检测有可能成为判断乳腺癌分期和预后的重要分子标志,并成为重要的预后因素.

Association research of expression of SULT1E1 with characteristic of clinical pathology and prognosis in breast cancer

OBJECTIVE: To clarify the expression of SULT1E1 in breast cancer and its relationship with clinicopathologic characteristics and prognosis of patients of breast cancer.METHODS: Expression of SULT1E1 protein was detected by the method of immunohistochemistry in 129 cases on cancerous and adjacent non-cancerous paraffin-embedded,then the prognosis of breast cancer was evaluated by Kaplan-Meier survival analysis,and the relationship between expression of SULT1E1 protein and clinicopathological indices was analyzed by statistics.RESULTS: The positive rate of SULT1E1 protein in breast cancer(25.6%) was significantly lower than that in normal breast tissues(45.0%).The positive rate of SULT1E1 protein in breast cancer was not related to age,tumor size,lymph node metastasis,pathological types or distant metastasis(P>0.05),Kaplan-Meier survival analysis showed that the survival rate of positive SULT1E1 protein expression patients was significantly higher than that of negative SULT1E1 protein expression patients(χ2=4.943,P<0.05).CONCLUSIONS: SULT1E1 protein is lower expressed in breast cancer,and it may relate to bad prognosis.It should be the important molecular marker to predict the clinicopathologic stage and prognosis of breast cancer.