| PI3K/Akt/mTOR信号通路抑制剂在乳腺癌中的研究进展 |
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| 引用本文： | 廖明娟,陈红风. PI3K/Akt/mTOR信号通路抑制剂在乳腺癌中的研究进展[J]. 中华肿瘤防治杂志, 2012, 19(3): 230-234 |
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| 作者姓名： | 廖明娟 陈红风 |
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| 作者单位： | 上海中医药大学附属龙华医院乳腺外科,上海,310022 |
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| 摘 要： | 目的:总结PI3K/Akt/mTOR信号通路靶向治疗在乳腺癌中的研究进展.方法:以“PI3K/Akt/mTOR、信号通路和乳腺癌”等为关键词,检索2000-01-2011-06 PubMed、Ovid和Springer等数据库的相关文献.纳入标准:1)关于PI3K/Akt/mTOR信号通路的组成、功能特点；2)PI3K/Akt/mTOR信号通路与乳腺癌的关系研究；3)以PI3K/Akt/mTOR信号通路中关键分子为靶点的乳腺癌治疗.根据纳入标准,符合分析的文献40篇.结果:信号转导通路的异常是肿瘤发生、发展的重要步骤,PI3K/Akt/mTOR信号通路与人类多种肿瘤密切相关,其在肿瘤细胞的增殖、存活、抵抗凋亡、血管发生和转移以及对放化疗抵抗中发挥了重要作用.乳腺癌中常见PI3K/Akt/mTOR信号通路的异常激活,以此通路为靶点的药物已成为乳腺癌治疗的研究热点.结论:靶向PI3K/Akt/mTOR通路中关键分子的众多药物在乳腺癌开展了一系列相关的临床试验研究,一部分显示出较好的安全性和有效性.随着对PI3K/Akt/mTOR通路的分子生物学机制的深入研究,期待靶向此通路的抑制剂将会在乳腺癌治疗中发挥巨大的作用,进一步提高乳腺癌患者的疗效和改善预后.
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| 关 键 词： | 乳腺肿瘤 靶向治疗 PI3K/Akt/mTOR 综述文献 |
Targeted therapy on PI3K/Akt/mTOR signaling pathway in breast cancer |
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| LIAO Ming-juan , CHEN Hong-feng. Targeted therapy on PI3K/Akt/mTOR signaling pathway in breast cancer[J]. Chinese Journal of Cancer Prevention and Treatment, 2012, 19(3): 230-234 |
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| Authors: | LIAO Ming-juan CHEN Hong-feng |
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| Affiliation: | Department of Breast Surgery,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 310022,P.R.China |
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| Abstract: | OBJECTIVE: To review the targeted therapy on PI3K/Akt/mTOR signaling pathway in breast cancer.METHODS:The following |
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| Keywords: | PI3K/Akt/mTOR,signaling pathway,breast cancer were nsed,and the database of PubMed,Ovid,Springer were searched The limited time was 2000-2010.Enrolled criteria: the composition and function of the signaling pathway,the aberation of it in breast cancer and targeted targeted therapies in clinical trials.Totally 167 related literatures were searched.Finally,40 literatures were included in this review.RESULTS: The abnormal activation of signal transduction pathways plays key roles in the occurrence and development of tumor.The PI3K/Akt/mTOR pathway is associated with multiple tumors,and it plays important roles in tumor cell proliferation,survival,anti-apoptosis,angiogenesis,metabolism,resistance to radiation and chemotherapy.The activation of the signal pathway is always occurred in breast cancer,the drugs have become hot spots.CONCLUSION: There are many drugs targeted the key molecules of PI3K/Akt/mTOR pathway for breast cancer in clinical trials,some studies have made promising results.With the fututher molecular biology mechanism research we expect to provide reference for studying breast cancer therapies which targeted the PI3K/Akt/mTOR pathway,and shows good safety and effectiveness and to improve effectiveness and prognosis of breast cancer patients. Key words: breast neoplasms targeted therapy PI3K/Akt/mTOR review literature |
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