广东省传染性非典型肺炎感染危险因素病例对照研究

目的了解SARS感染的危险因素。方法选择2002年11月16日至2003年6月30日广东省报告的符合“卫生部《传染性非典型肺炎临床诊断标准(试行)》”的病例,在病例的邻居中选择与病例年龄相差不超过5岁,性别相同,无接触史且无发病者作为对照,采用回顾性调查方法,调查内容包括一般情况、流行病学史、家庭环境、工作场所环境、个人饮食和卫生情况。采用单因素和多因素Logistic回归分析方法进行比较。结果共调查病例809例、对照331例。多因素条件Logistic回归分析结果表明,发病前20 d有外县旅行史(OR=1.82,95%CI为1.05~3.17)、去过医院(OR=1.59,95%CI为1.06~2.39),有SARS/可疑SARS病例接触史(OR=1.66,95%CI为1.33~2.08)和有动物接触史(OR=1.53,95%CI为1.05~2.24)是SARS感染的危险因素,工作场所通风良好(OR=0.56,95%CI为0.41~0.76)是SARS感染的保护因素。结论接触SARS或可疑SARS病例、去过医院、有外县旅行史和有接触动物史是SARS感染的危险因素。

A case-control study to examine the risk factors of SARS infection in Guangdong province

Objective To explore the risk factors of severe acute respiratory syndrome(SARS) infection in Guangdong Province.Methods Related factors were analysed used with logistic regression.Results 809 SARS patients and 331 controls were investigated.Risk factors of SARS infection were case contact(OR=1.66,95%CI 1.33-2.08),travel(OR=1.82,95%CI 1.05-3.17),hospital visiting(OR=1.59,95%CI 1.06-2.39) and animal contact(OR=1.53,95%CI 1.05-2.24).Good ventilation(OR=0.56,95%CI 0.41-0.76) was protective factor.Conclusion Case contact,animal contact,travel and hospital visiting were risk factors of SARS infection.